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Important News

by Ed 0 Comments

Hello Unhinged fans and listeners. This is Ed, co-founder and co-host of the podcast. As you may have noticed, we haven’t posted much in the last few days. There’s a reason for that, and it’s unfortunately not great news.

As many of you have seen, Doug recently posted about his two-month remission and how he’s been cautiously optimistic about recovery. As a matter of fact, our next show, episode #16, which is scheduled to be released on July 12th, is all about his remission and some interesting new facts he learned about the origins of his mental illness. The show has already been recorded, and it’s a mostly positive discussion.

However, for the past several days, Doug has taken a turn for the worse and is again experiencing debilitating symptoms. He is very angry, depressed, and frustrated to say the least. He has no energy to move and even skipped out on going to a baseball game that someone gave him tickets to, which he was excited about just last week. I’ve been trying to motivate him to change his routine to no avail. We’ve talked, but all that comes out of his mouth is negativity and anger, which makes it very difficult to have a productive conversation.

Underneath it all, he knows and understands that it is the disease talking, and I get that too. But I won’t lie and say it’s easy to take. It’s not. I miss the real Doug, the one who had me in tears laughing when we recorded some of our silly bits in episode #13. I miss the Doug that I can talk to for hours about music and comedy. And I miss the Doug that is positive and thinking about how well he is doing fighting to get his life back. The Doug I’ve been talking to the last few days is a false one, taken over by an evil beast of a disease. The hardest parts are those fleeting moments where his true self bleeds through, if only for a sentence or two. Like he’s fighting to get a message out to me that says “don’t listen to him, that’s not me!”

I hear you, brother. And I’m still here for you, waiting.

In the meantime, I am trying to get an update recorded and added to our next show to explain to our listeners that the remission has decided to take a little break for now. Not sure what we’ll do for the show after that, but we’ll take it one day at a time.

Thank you all again for your continued support.

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Stephen Fry on Depression

by Ed 0 Comments

If you know someone who is depressed, please resolve never to ask them why. Depression isn’t a straightforward response to a bad situation. Depression just is, like the weather.

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An Unconditional Thank you to Mr. Unconditional

by Doug 0 Comments

I IMG_20160623_180359want to send a special thank you to my best friend Ed Caggiani for helping me get through the last couple of days which have been quite difficult, to say the least.

He was, as usual, unconditionally supportive and helped me through a difficult time financially as well.

He was also an ideal “enabler” (Not in the traditional sense!)

Sorry, but you’ll have to tune in to Episode #14 of Unhinged Podcast, to be released on June 28th, for more gory details, as well as other open, honest and unedited confessions…true talk amongst true friends.

For us and for you, don’t miss it! -Talking Mental

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Yawning and the Brain

by Doug 0 Comments



Yawning is a stereotyped behavior with very ancient origins, for it is found in fish, reptiles, and birds, as well as in humans. Described in ancient times by Hippocrates (who thought it served to evacuate fever), yawning did not become a subject of serious interest until the advances achieved in neuroscience in the 1980’s.

Generally speaking, yawning consists of three phases: first, a long intake of air, then a climax, and finally a rapid exhalation, which may or may not be accompanied by stretching. After yawning, you generally experience a sense of well being and relaxation and feel much more present in and aware of your body than you did before you yawned.

Contrary to what was believed for centuries, yawning does not serve to improve oxygenation in the brain. This myth was first laid to rest when it was discovered that the human fetus can yawn as early as the age of 12 weeks, even though it is surrounded by amniotic fluid in its mother’s belly and so is scarcely likely to get any more oxygen to its brain from this effort.

Second, if yawning really helped to raise the oxygen concentration in the blood, then inhaling pure oxygen would cause yawns to become less frequent, while raising the concentration of carbon dioxide in the blood would make them more frequent. But several studies have shown that neither of these things occurs. Also, yawning is no more common in people with acute or chronic respiratory problems than it is in the general population.

The role of yawning has yet to be fully determined. But because we yawn more often when we first awaken, when we are bored, and when we are trying not to fall asleep, its primary function would appear to be to help make us more alert. Yawning also seems to play a role in non-verbal communication, especially among primates.

Which leads us to something truly singular about yawning: its contagiousness. That is, when we see someone yawn, it makes us yawn. Sometimes simply thinking about a yawn can be enough to trigger one! Obviously, the term “contagiousness” should not be taken literally here, because no germs are being transmitted. More precisely, yawning is a form of involuntary imitation. Some scientists believe that this characteristic of yawning may have developed as a mechanism for promoting social cohesion, for example, by enabling all the people present in a group to have the same level of alertness at the same time.

In the rest of the animal kingdom, yawning is observed among predator and prey species alike. Among predators, its purpose might be to encourage the group to take a restorative nap so that all of its members can be well rested for an attack on their prey later on. Among prey, by encouraging all members of the group to fall asleep at the same time, yawning might reduce the risk that any one individual might be sleeping alone and hence highly vulnerable to attack by a predator.

There is no nerve centre strictly associated with the yawn reflex, but certain brain structures, such as the hypothalamus, the pituitary gland, and the brainstem are essential for its expression. Some scientists have even hypothesized that the strong contractions of the jaw muscles during yawning may stimulate the reticular formation and thereby encourage wakefulness.

Lastly, one interesting linguistic note: the French verb bâiller (to yawn) has a circumflex accent on the “a” and not on the “i” because in Old French, when people pronounced this word, they stretched out the “a” to imitate the sound of someone yawning.

*Courtesy of McGill University -“The Brain, Start to Finish”                                                                                 copyleft

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Doug’s 2nd Consultation with Dr. Roger S. McIntyre

by Doug 0 Comments

Dr. Roger S. McIntyre

Monday June 6th, 2016 -Met with Dr. McIntyre today for my 2nd consult with him. Now that the DBS is working to some degree, will Dr. McIntyre have some insight into whether or not supplementation on the biochemical side will possibly help the DBS in it’s work? And what does his latest research suggest, given my mood, fluctuation patters, and from a full-scale picture, in the way of medications that are NOT typically used for TRD.

 *More in tomorrow’s post; and you won’t believe what he said…

Dr. Roger S. McIntyre MD, FRCPC
Head, Mood Disorders Psychopharmacology Unit (UHN)

Dr. Roger McIntyre is currently a Professor of Psychiatry and Pharmacology at the University of Toronto and the Head of the Mood Disorders Psychopharmacology Unit at the University Health Network, Toronto, Canada.

He was named by Thomson Reuters in 2014 as one of “The World’s Most Influential Scientific Minds”. This distinction is bestowed upon researchers who publish the most highly cited articles in a variety of scientific fields during the previous decade.

He is also extensively involved in medical education.  He is a highly sought-after speaker at both national and international meetings. He has received several teaching awards from the University of Toronto’s Department of Psychiatry and has been selected for the joint Canadian Psychiatric Association (CPA)/Council of Psychiatric Continuing Education Award for the Most Outstanding Continuing Education Activity in Psychiatry in Canada.

Dr. McIntyre is the co-chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force on the Treatment of Comorbidity in Adults with Major Depressive Disorder or Bipolar Disorder and as well a contributor to the CANMAT guidelines for the treatment of Depressive Disorders and Bipolar Disorders. He has published hundreds of peer-reviewed articles and has edited and/or co-edited several textbooks on mood disorders.

He completed his medical degree at Dalhousie University and completed his Psychiatry residency training and Fellowship in Psychiatric Pharmacology at the University of Toronto.

Research Interests

Dr. McIntyre is involved in multiple research endeavours which aim to characterize the association between mood disorders, especially cognitive function and medical comorbidity.  Broadly, his work aims to characterize the underlying causes of cognitive impairment in individuals with mood disorders and their impact on workplace functioning. This body of work has provided a platform for identifying novel molecular targets to treat and prevent mood disorders and accompanying cognitive impairment.


Dr.McIntyre’s UHN Profile

Dr.McIntyre’s Research Publications

Dr. Roger McIntyre: Mood Disorders and Metabolic-Inflammatory Comorbidity -YouTube Video


Toronto Western Hospital (UHN)

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