pharmacogenetics Archives - Unhinged

Unhinged Episode #016: Mission Remission

by Ed 0 Comments
Unhinged Episode #016: Mission Remission

NOTE: This podcast was recorded on July 3rd and deals with Doug’s recent 2-month remission. However, as of July 4th, Doug’s mood has taken a downward turn, so the declaration of a full remission was a bit premature. We will have more information about this on next week’s show, so please stay tuned. In the meantime, please enjoy episode #16.

This week’s episode deals with Doug’s recent two-month remission. Technically, a two-month period with no major depressive symptoms is considered a full remission. This is where he is right now, but how long will it last?

We also learn about the true origins of Doug’s mental illness. There is now scientific proof that his genetics have a great deal to do with his treatment-resistant depression. The good news is that a DNA profile, combined with advanced brain imaging techniques, helps doctors more accurately try different therapies and medications that are better targeted at an individual. This should help usher out the era of stab-in-the-dark medicine, and begin a new era of targeted, customized, and more effective treatments.

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Unhinged Episode #012: Psychopharmacology and Pharmacogenetics

by Ed 0 Comments
Unhinged Episode #012: Psychopharmacology and Pharmacogenetics

This week we talk about drugs and how genetics might play a part in how they affect different people. Doug , as part of an IMPACT study in pharmacogenetics, discovers he metabolizes slowly, so medicinal treatments need to be adjusted accordingly. We also discuss his battles with the Ministry of Health and drugs not covered by the Ontario Health Insurance Plan (OHIP).

Ed takes the Hamilton Depression Scale test (HAM-D) to measure his depression level. How does the supposedly “normal” half of the Unhinged team rate? Doug also covers helpful tools for depressive disorder, including diet, positive self-talk, journaling, and more.

And finally, we get a progress report on Doug’s current state. What did he score on the HAM-D test?

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