Neuroscience Archives - Unhinged

Attention UH Listeners:

by Doug 0 Comments

Please note: There will be no podcast this week, as I am celebrating a birthday on Tuesday, Ed is still settling into his new Colorado spread, and most importantly, we need the week to work on some technical issues, to get back to the level of production quality that we’re used to and insist on. Thank you for your support & patience.

The next show, show #43, will be released on Tuesday, March 29th.

Cheers,

Doug Warren

Unhinged Podcast -Talking Mental

 

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Current State of the UHN Deep Brain Stimulation (DBS) Clinical Trial

by Doug 0 Comments

Deep brain stimulation (DBS) is currently the most powerful known treatment for major depression.  The technique itself was developed at the Toronto Western Hospital nearly 10 years ago.  It was based on research findings by neurologist Dr. Helen Mayberg, working with a multi-disciplinary team that included world-renowned neurosurgeon Dr. Andres Lozano, our own Clinic’s Co-Director, Dr. Peter Giacobbe, as well as UHN’s Psychiatrist-in-Chief, Dr. Sidney Kennedy.  Because DBS can often achieve remission where all other measures fail, the tecnhique is now being used to treat severe depression in advanced medical centres across Canada and around the world.

With DBS, a neurosurgeon implants a pair of electrodes into a small brain structure that is overactive in depression, called Area 25, or the subgenual cingulate.  The electrodes stimulate at a high frequency that effectively jams the signals passing through the neural connections in the region.  Once the electrodes are activated, many patients experience a rapid and dramatic improvement in symptoms — even patients who have not responded to any other treatment, including ECT.  However, DBS remains an experimental technique, available only to small numbers of patients, in medical centres with expert teams of neurosurgeons.  It also requires the electrodes to be permanently implanted in the brain and connected to a battery implanted under the collarbone — quite an invasive procedure compared to other treatments for depression.  For these reasons, DBS is usually reserved for cases where all other options have failed.

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Unhinged Podcast is Back!

by Doug 2 Comments

Show #42 will be available everywhere, including at UnhingedPodcast.com, August 15th!

We’ve been on hiatus since March, as Doug has gone through a nasty & long relapse. With the help of the UHN Neuroscience & Neuropsychiatry team, it looks like there has been some signs of improvement, and we’re hoping that Doug will get back to that very good quality remission he’d experienced several months ago. Until the neuromodulator battery died and surgery was performed…and once again leading to a complete relapse.

We’ll get more in detail on his current status with show 42, as well as a couple of hot topics due for discussion, and more. We’re very excited to get things going again full-throttle. We want to thank you, our loyal listeners, fellow advocates and dear friends for being so patient and understanding during the ups & downs. Please know that we’re dedicated & passionate about what we’re doing, and we want to be with you every Tuesday, as we’d done for so long.

So, mark your calendars and don’t miss Show #42, it will be a real occasion for us, and we can’t wait to get back to doing what we do. “See” You Then!

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Today’s Post-Surgery f/u with Dr. Peter Giacobbe

by Doug 0 Comments

Today I’ll be meeting with Dr. Peter Giacobbe, of the Neuroscience clinic at Toronto Western Hospital, for my post-surgery check-in and possible adjustments​ to the neuromodulator.

I’m hoping with everything I’ve got that the DBS, with the current settings, will resume working as it had done for over 3 months prior to the battery running low. It was by far the best quality remission (out of 3 total) that I’ve had to date.

#Hope is what I’m riding on…

“We must accept finite disappointment, but never lose infinite hope.” ~Martin Luther King, Jr 

~Doug

Unhinged Podcast -Talking Mental

Hope for Remission Continued…

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Unhinged Episode #025: Carpe Diem

by Ed 0 Comments
Unhinged Episode #025: Carpe Diem

In this episode we continue discussing Doug’s progress and how the MEG brain imaging has helped dial in his current DBS settings, which seem to be holding so far. Doug goes into a bit of detail about the differences between the types of brain imaging currently available and their specific uses.

We also talk about Dr. Harry Frederick Harlow’s emotional experiments with rhesus monkeys, the ethical concerns surrounding his methods, and what we learned from his results. Also, we bring up Robin Williams again and discuss a few more details about his mental illness, and the similarities to Doug’s intractable depression.

Lastly, we talk about how we need to seize the day and appreciate everything we have right now and not stress out about what we cannot control. As Doug is improving, he is seeing the world through new eyes, hungry for everything positive the world has to offer.

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Yawning and the Brain

by Doug 0 Comments

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Yawning is a stereotyped behavior with very ancient origins, for it is found in fish, reptiles, and birds, as well as in humans. Described in ancient times by Hippocrates (who thought it served to evacuate fever), yawning did not become a subject of serious interest until the advances achieved in neuroscience in the 1980’s.

Generally speaking, yawning consists of three phases: first, a long intake of air, then a climax, and finally a rapid exhalation, which may or may not be accompanied by stretching. After yawning, you generally experience a sense of well being and relaxation and feel much more present in and aware of your body than you did before you yawned.

Contrary to what was believed for centuries, yawning does not serve to improve oxygenation in the brain. This myth was first laid to rest when it was discovered that the human fetus can yawn as early as the age of 12 weeks, even though it is surrounded by amniotic fluid in its mother’s belly and so is scarcely likely to get any more oxygen to its brain from this effort.

Second, if yawning really helped to raise the oxygen concentration in the blood, then inhaling pure oxygen would cause yawns to become less frequent, while raising the concentration of carbon dioxide in the blood would make them more frequent. But several studies have shown that neither of these things occurs. Also, yawning is no more common in people with acute or chronic respiratory problems than it is in the general population.

The role of yawning has yet to be fully determined. But because we yawn more often when we first awaken, when we are bored, and when we are trying not to fall asleep, its primary function would appear to be to help make us more alert. Yawning also seems to play a role in non-verbal communication, especially among primates.

Which leads us to something truly singular about yawning: its contagiousness. That is, when we see someone yawn, it makes us yawn. Sometimes simply thinking about a yawn can be enough to trigger one! Obviously, the term “contagiousness” should not be taken literally here, because no germs are being transmitted. More precisely, yawning is a form of involuntary imitation. Some scientists believe that this characteristic of yawning may have developed as a mechanism for promoting social cohesion, for example, by enabling all the people present in a group to have the same level of alertness at the same time.

In the rest of the animal kingdom, yawning is observed among predator and prey species alike. Among predators, its purpose might be to encourage the group to take a restorative nap so that all of its members can be well rested for an attack on their prey later on. Among prey, by encouraging all members of the group to fall asleep at the same time, yawning might reduce the risk that any one individual might be sleeping alone and hence highly vulnerable to attack by a predator.

There is no nerve centre strictly associated with the yawn reflex, but certain brain structures, such as the hypothalamus, the pituitary gland, and the brainstem are essential for its expression. Some scientists have even hypothesized that the strong contractions of the jaw muscles during yawning may stimulate the reticular formation and thereby encourage wakefulness.

Lastly, one interesting linguistic note: the French verb bâiller (to yawn) has a circumflex accent on the “a” and not on the “i” because in Old French, when people pronounced this word, they stretched out the “a” to imitate the sound of someone yawning.

*Courtesy of McGill University -“The Brain, Start to Finish”                                                                                 copyleft

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Renowned neurosurgeon, and my DBS doc, Andres Lozano on TED (Jan 2013)

by Doug 0 Comments

Parkinson’s, depression and the switch that might turn them off

Deep brain stimulation is becoming very precise. This technique allows surgeons to place electrodes in almost any area of the brain, and turn them up or down — like a radio dial or thermostat — to correct dysfunction. Andres Lozano offers a dramatic look at emerging techniques, in which a woman with Parkinson’s instantly stops shaking and brain areas eroded by Alzheimer’s are brought back to life. (Filmed at TEDxCaltech.)

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