Doug, Author at Unhinged

Relational Memory and the Hippocampus

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Declarative memory – Memory for facts and events, to be contrasted with procedural memory, which supports the ability to acquire and express skills (or the difference between “knowing that” and “knowing how”). The nature of declarative representations, thought to be fundamentally relational and flexible, makes it possible for such memory to be consciously accessed and “declared”.

Explicit memory – A kind of memory based on explicit remembering or conscious recollection of some prior learning episode, or the kind of memory test that requires explicit remembering; usually defined in contrast to implicit memory, involving the ability of behavior to be influenced by previous experience without requiring the individual to consciously recollect the prior experience.

Recollection – A process that results in the retrieval of additional information about a particular item from memory beyond its oldness; this information could be some detail of the study experience such as the color of the font of the item or its location on the screen, or some internal state at study time, such as what the item reminded you of.

Relational memory – Memory for relations among the constituent elements of experience, providing the ability to remember names with faces, the locations of various objects or people, or the order in which various events occurred. Can be contrasted to item memory, i.e., of the individual elements themselves. The hippocampus is required for memory for arbitrary or accidentally occurring relations.

Place cells – When an animal is exploring its environment, principal neurons of the hippocampus fire preferentially in particular regions of the environment corresponding to the neurons’ “place fields”; in this way, a set of such neurons can represent the entire environment. The “places” are represented relationally, in terms of the relations among elements in the environment.

Source memory – Memory for information about an item beyond the item itself; i.e., its various relations to other elements of the event. In laboratory experiments, this usually refers to the particular location of an item on the computer screen, the color of the font or format in which the item is displayed, or the voice or identity associated with some piece of presented information.

Unitization – The fusing, blending, or configuring of multiple aspects of a sensory array into a single-item representation; thought to be accomplished by cortical regions outside of the hippocampus [such as in the fusiform face area (FFA) for faces, and the perirhinal cortex for some complex objects], and less flexible and less relational than hippocampal representations of multiple objects.

*NCBI -National Center for Biotechnology Information

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World Suicide Prevention Day -September 10, 2017

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Join in on World Suicide Prevention Day

2017 marks the 15th World Suicide Prevention Day. The day was first recognized in 2003, as an initiative of the International Association for Suicide Prevention and endorsed by the World Health Organization. World Suicide Prevention Day takes place each year on September 10.

On September 10, join with others around the world who are working towards the common goal of preventing suicide. Show your support by taking part in our Cycle Around the Globe campaign aimed at raising awareness through community action. Find out what local activities have been scheduled as well – or initiate one yourself!

Finally, if there is anyone you are concerned about, take a minute to check in with them. It could change their life.

Ride with us! World Suicide Prevention Day – Cycle Around the Globe: https://goo.gl/DFZCE3

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Attention UH Listeners:

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Please note: There will be no podcast this week, as I am celebrating a birthday on Tuesday, Ed is still settling into his new Colorado spread, and most importantly, we need the week to work on some technical issues, to get back to the level of production quality that we’re used to and insist on. Thank you for your support & patience.

The next show, show #43, will be released on Tuesday, March 29th.

Cheers,

Doug Warren

Unhinged Podcast -Talking Mental

 

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Current State of the UHN Deep Brain Stimulation (DBS) Clinical Trial

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Deep brain stimulation (DBS) is currently the most powerful known treatment for major depression.  The technique itself was developed at the Toronto Western Hospital nearly 10 years ago.  It was based on research findings by neurologist Dr. Helen Mayberg, working with a multi-disciplinary team that included world-renowned neurosurgeon Dr. Andres Lozano, our own Clinic’s Co-Director, Dr. Peter Giacobbe, as well as UHN’s Psychiatrist-in-Chief, Dr. Sidney Kennedy.  Because DBS can often achieve remission where all other measures fail, the tecnhique is now being used to treat severe depression in advanced medical centres across Canada and around the world.

With DBS, a neurosurgeon implants a pair of electrodes into a small brain structure that is overactive in depression, called Area 25, or the subgenual cingulate.  The electrodes stimulate at a high frequency that effectively jams the signals passing through the neural connections in the region.  Once the electrodes are activated, many patients experience a rapid and dramatic improvement in symptoms — even patients who have not responded to any other treatment, including ECT.  However, DBS remains an experimental technique, available only to small numbers of patients, in medical centres with expert teams of neurosurgeons.  It also requires the electrodes to be permanently implanted in the brain and connected to a battery implanted under the collarbone — quite an invasive procedure compared to other treatments for depression.  For these reasons, DBS is usually reserved for cases where all other options have failed.

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Unhinged Podcast is Back!

by Doug 2 Comments

Show #42 will be available everywhere, including at UnhingedPodcast.com, August 15th!

We’ve been on hiatus since March, as Doug has gone through a nasty & long relapse. With the help of the UHN Neuroscience & Neuropsychiatry team, it looks like there has been some signs of improvement, and we’re hoping that Doug will get back to that very good quality remission he’d experienced several months ago. Until the neuromodulator battery died and surgery was performed…and once again leading to a complete relapse.

We’ll get more in detail on his current status with show 42, as well as a couple of hot topics due for discussion, and more. We’re very excited to get things going again full-throttle. We want to thank you, our loyal listeners, fellow advocates and dear friends for being so patient and understanding during the ups & downs. Please know that we’re dedicated & passionate about what we’re doing, and we want to be with you every Tuesday, as we’d done for so long.

So, mark your calendars and don’t miss Show #42, it will be a real occasion for us, and we can’t wait to get back to doing what we do. “See” You Then!

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Today’s Post-Surgery f/u with Dr. Peter Giacobbe

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Today I’ll be meeting with Dr. Peter Giacobbe, of the Neuroscience clinic at Toronto Western Hospital, for my post-surgery check-in and possible adjustments​ to the neuromodulator.

I’m hoping with everything I’ve got that the DBS, with the current settings, will resume working as it had done for over 3 months prior to the battery running low. It was by far the best quality remission (out of 3 total) that I’ve had to date.

#Hope is what I’m riding on…

“We must accept finite disappointment, but never lose infinite hope.” ~Martin Luther King, Jr 

~Doug

Unhinged Podcast -Talking Mental

Hope for Remission Continued…

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